Education and Professinal Appointment: 2018.1 - Present: Associate Professor, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 2014.11 - 2018.1: Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 2011.9 - 2014.11: Ph.D. candidate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. 2009.9 - 2011.9: M.S., Kunming Institute of Zoology, the Chinese Academy of Sciences 2004.9 - 2009.6: B.A., College of Animal Medicine, Huazhong Agricultural University
Publication: First author: 1. Zeng J#, Xie X#, Feng X-L#, Xu L#, Han J-B, Yu D, Zou Q-C, Liu Q, Li X, Ma G, Li M-H*, Yao Y-G*. 2022. Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. EBioMedicine, 75: 1038. 2. Xu L#, Yu D#, Yao Y-L, Gu T, Zheng X, Wu Y, Luo R-H, Zheng Y-T, Zhong J, Yao Y-G*. 2020. Tupaia MAVS is a dual target during hepatitis C virus infection for innate immune evasion and viral replication via NF-¦ÊB. The Journal of Immunology, 205: 2091-2099. 3. Xu L#, Yu D#, Ma Y, Yao Y-L, Luo R, Feng X, Cai H, Han J, Wang X, Li M, Ke C, Zheng Y-T*, Yao Y-G*. 2020. COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2. Zoological Research, 41: 517-526. 4. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao Y-L, Zhong J, Chen X, Yao Y-G*. 2020. An alternative splicing of Tupaia STING modulated anti-RNA virus responses by targeting MDA5-LGP2 and IRF3. The Journal of Immunology, 204: 3191-3204. 5. Xu L, Yu D, Fan Y, Liu Y-P, Yao Y-G*. 2019. Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I. Journal of Genetics and Genomics, 46: 499-503. 6. Xu L, Peng L, Gu T-L, Yu D, Yao Y-G*. 2019. The 3¡äUTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1862: 47-57. 7. Xu L#, Yu D#, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955. Corresponding author: 1. Gu T-L, Yu D, Fan Y, Wu Y, Yao Y-L, Xu L*, Yao Y-G*. 2019. Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis). Developmental and Comparative Immunology, 96: 27-36. Others: 1. Gu T, Yu D, Xu L, Yao Y-L, Yao Y-G*. 2021. Tupaia GBP1 interacts with STING to initiate autophagy and restrict herpes simplex virus type 1 infection. The Journal of Immunology, 207: 2673-2680. 2. Zheng X, Xu L, Ye M, Gu T, Yao Y-L, Lv L-B, Yu D*, Yao Y-G*. 2022. Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections. Developmental and Comparative Immunology, 127: 104307. 3. Liu Q, Gu T, Su L-Y, Jiao L, Qiao X, Xu M, Xie T, Yang L-X, Yu D, Xu L, Chen C*, Yao Y-G*. 2021. GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. Redox Biology, 47: 102172. 4. Ye M, Zhang J-Y, Yu D, Xu M, Xu L, Lv L-B, Zhu Q-Y, Fan Y, Yao Y-G*. 2021. Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing. Zoological Research, 42: 692-709. 5. Gu T, Yu D, Xu L, Yao Y-L, Zheng X, Yao Y-G*. 2021. Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome. Cytokine, 138: 155388. 6. Yao Y-L, Yu D, Xu L, Gu T, Li Y, Zheng X, Bi R, Yao Y-G*. 2020. Tupaia OASL1 promotes cellular antiviral immune responses by recruiting MDA5 to MAVS. The Journal of Immunology, 205: 3419-3428. 7. Gu T-L, Yu D, Li Y, Xu L, Yao Y-L, Yao Y-G*. 2019. Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Applied Microbiology and Biotechnology, 103: 2171-2180. 8. Yao Y-L, Yu D, Xu L, Fan Y, Wu Y, Gu T-L, Chen J, Lv L-B, Yao Y-G*. 2019. Molecular characterization of the 2¡ä,5¡ä-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis). Cytokine, 114: 106-114.
Hobby: reading, travel, music